Teguh Aryanugraha and Harjanto Joso Muljono and Lilik Herawati (2012) Effect of combined 500 mg vitamin c and 200 iu vitamin e on plasma malondialdehyde level after physical exercise in diving athletes. Jurnal Folia Medica Indonesiana, 48 (4). pp. 156-162. ISSN 2252-8199

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Abstract

Every day we are exposed to oxidants. Excessive oxidants may cause various diseases in human body. Oxidants may appear as part of a regular metabolic activity, lifestyle, diet, exogenous exposure, and physical activity. Athletes, including diving athletes, are group that have a risk factor of oxidative stress because of high-intensity physical exercise. Vitamin C and vitamin E are part of the body's defense system against oxidants. However, combination dose of 500 mg of vitamin C and 200 IU of vitamin E in the diving athletes is still not clear. Thirteen diving athletes used as research subjects were divided into two groups. Group A was given a combination of 500 mg of vitamin C and 200 IU of vitamin E for five days and group B was given placebo. On the sixth day, pre-exercise plasma MDA was taken in minute 0, then each athlete was given 100 mg glucose solution + 200 cc water. We started counting minutes since the intake of glucose. Then, the athletes were undergoing physical exercise by diving. In the 30th minute and 60 minutes after glucose intake we took post-prandial plasma MDA. Results of data analysis using paired T test showed significant difference in exercise plasma MDA levels with plasma MDA levels 30' PP in group A and B (p < 0,05). Not-significant differences (p > 0.05) was obtained from the analysis of plasma MDA 30' PP with plasma MDA and MDA plasma 60' PP pre-exercise with plasma MDA 60' PP. Unpaired t test between group A and group B showed no significant difference in plasma MDA levels in any retrieval time (p > 0,05). From these results, it can be concluded that the combination dose of 500 mg vitamin C and 200 IU of vitamin E does not affect plasma MDA levels in athletes, but there is a trend of slightly increase in mean MDA. This could be due to the effects of exogenous antioxidants in reducing free radicals.

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