Putu Niken Ayu Amrita (2019) Hubungan Antara Kadar Feritin Serum Dengan Jumlah CD4, CD8, DAN RASIO CD4/CD8 Pada Pasien Thalassemia Beta Dewasa Tergantung Transfusi: Penelitian Observasional Cross Sectional Di Poliklinik Onkologi Satu Atap Hemato-Onkologi Medik Penyakit Dalam Instalasi Rawat Jalan RSUD Dr.Soetomo Surabaya. Thesis thesis, UNIVERSITAS AIRLANGGA.

	Text (HALAMAN JUDUL) 1. HALAMAN JUDUL .pdf Download (123kB)
	Text (ABSTRACT) 2. ABSTRACT.pdf Download (36kB)
	Text (DAFTAR ISI) 3. DAFTAR ISI.pdf Download (68kB)
	Text (BAB 1) 4. BAB 1 PENDAHULUAN.pdf Download (127kB)
	Text (BAB 2) 5. BAB 2 TINJAUAN PUSTAKA.pdf Restricted to Registered users only until 10 August 2023. Download (284kB) | Request a copy
	Text (BAB 3) 6. BAB 3 KERANGKA KONSEPTUAL DAN HIPOTESA PENELITIAN.pdf Restricted to Registered users only until 10 August 2023. Download (120kB) | Request a copy
	Text (BAB 4) 7. BAB 4 METODE PENELITIAN.pdf Restricted to Registered users only until 10 August 2023. Download (113kB) | Request a copy
	Text (BAB 5) 8. BAB 5 HASIL PENELITIAN.pdf Restricted to Registered users only until 10 August 2023. Download (118kB) | Request a copy
	Text (BAB 6) 9. BAB 6 PEMBAHASAN.pdf Restricted to Registered users only until 10 August 2023. Download (77kB) | Request a copy
	Text (BAB 7) 10. BAB 7 KESIMPULAN DAN SARAN.pdf Restricted to Registered users only until 10 August 2023. Download (19kB) | Request a copy
	Text (DAFTAR PUSTAKA) 11. DAFTAR PUSTAKA.pdf Download (76kB)
	Text (LAMPIRAN) 12. LAMPIRAN.pdf Restricted to Registered users only until 10 August 2023. Download (450kB) | Request a copy

Abstract

Background: Chronic blood transfusions and hemolysis are the major causes of secondary iron overload in transfusion dependent Thalassemia Beta. Iron overload can cause several organ complication including immune alteration. Infection due to immune alteration is number two leading cause of mortality in thalassemia. Research on the correlation of ferritin as iron overload marker and T lymphocyte subsets alteration in adult transfusion are still rare and requires further study Objective: To study the correlation of iron overload and T lymphocyte subsets CD4, CD8 and CD4/CD8 ratio in adult transfusion dependent beta thalassemia. Methods: The study was cross sectional observational analytic study conducted on 36 subjects with transfusion dependent beta thalassemia diagnosed by clinical examination and laboratory High Performance Liquid Chromatography followed up at Hematology Clinic, dr Soetomo Teaching Hospital Surabaya, Indonesia. Ferritin serum were measured by chemiluminiscence immunoassay (CLIA) method, while CD4, CD8 counts and CD4/CD8 ratio were assessed by flowcytmetry with antigen for CD3/CD4/CD8 Results: There were 36 subjects, 21 males and 15 females with median age of 23 (range 18- 48). The mean ferritin serum was 5137,8 + 2433,5 ng/ml while CD4, CD8 and CD4/CD8 ratio were 695, 56+ 251,17; 822,4+ 360 and 0,95 +0,42 respectively. Analysis of correlation showed there’s correlation of Ferritin and CD4 (r = -0,34, p< 0.05), ferritin and CD8 (r = 0,43, p <0.03) and ferritin and CD4/CD8 ratio (r = 0,34, p< 0.05) Conclusion: In this study there were correlation of ferritin serum and CD4, CD8 and CD4/CD8 ratio. An increase of ferritin in iron overload will decrease CD4, increase CD8 and decrease CD4/CD8 ratio

Actions (login required)

View Item