Dzikrina Ilmanita (2020) Korelasi Antara Kadar Nerve Growth Factor (NGF) Serum Dan Intensitas Nyeri Setelah Pemberian Kombinasi Parasetamol-Amitriptilin Pada Pasien Nyeri Punggung Bawah Kronik (Penelitian dilakukan di URJ Penyakit Saraf RSUD Dr. Soetomo Surabaya). Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background - The effectiveness of paracetamol-amitriptyline combination therapy had not been proved yet. Nerve Growth Factor (NGF) is a neurotrophin involved in the pathophysiology of chronic low back pain (LBP). The previous study had proven the correlation of NGF and pain intensity in chronic migraine but similar study had never been conducted in chronic LBP. Objective – This study was aimed to analyze the correlation between serum NGF levels and pain intensity after the administration of paracetamol-amitriptyline combination in chronic LBP patients. Method – Serum NGF levels and pain intensity data were collected before and after chronic low back pain patients had been using therapy consists of the combination of paracetamol 500 mg thrice daily and amitriptyline 10 mg once daily as needed. Pain intensity was assessed with the visual analog scale (VAS) and pain rating index (PRI) of the short form - McGill pain questionnaire (SF-MPQ). Results – The positive correlation between VAS and serum NGF levels after therapy was negligible (r = 0.093). The positive correlation between PRI SF-MPQ and serum NGF levels after therapy was weak (r = 0.145). The positive correlation between the change of PRI SF-MPQ and serum NGF levels was weak (r = 0.239). Paracetamol-amitriptyline combination could decrease pain intensity VAS (p = 0.001) and PRI SF-MPQ (p = 0.012) significantly. Conclusion – There was no correlation between serum NGF levels and VAS pain intensity, but there was a weak positive correlation between serum NGF levels and PRI SF-MPQ after the administration of paracetamol-amitriptyline combination in chronic LBP patients.

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