Deasy Ardiany and Soebagijo Adi Soelistijo and Ari Sutjahjo and Askandar Tjokroprawiro (2017) Hemoglobin A1C as the Strongest Influencing Factor in relation to Vascular Stiffness in Type 2 Diabetes Mellitus - Metabolic Syndrome Patients. In: Proceedings of Surabaya International Physiology Seminar: SIPS. Scitepress, Surabaya, pp. 331-335. ISBN 978-989-758-340-7

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Abstract

The risk of cardiovascular disease in type 2 diabetes mellitus (T2DM) will be high despite intensive glycemic control. This is because T2DM is often accompanied by the condition of metabolic syndrome (MetS). Endothelial dysfunction can be assessed by non-invasive pulse wave velocity (PWV) measurement, which is an arterial stiffness influencing factor. This research aimed to determine the correlation of influencing factors in regard to metabolic syndrome and HbA1c in relation to vascular stiffness as measured by baPWV value in T2DM-Mets. The research was conducted at the Diabetes Outpatient Clinic of Dr. Sutomo General Hospital Surabaya and six Primary Healthcare clinics in Surabaya from December 21, 2010 - March 21, 2012. Subjects fulfilling the inclusion and exclusion criteria were measured with regard to blood pressure, BMI, waist circumference, laboratory examination: Fasting plasma glucose, Post prandial glucose, Hemoglobin A1c and ba-PWV measurements with V Serra-1000 devices. A total of 33 patients with T2DM met the inclusion and exclusion criteria. The result of the statistical analysis shows that there is a significant correlation between the HbA1c value and ba-PWV (p = 0.036). Other influencing factors exhibited a non-significant correlation with vascular stiffness (p >0.05). The contribution of metabolic syndrome and HbA1c influencing factors was 4.6% with respect to vascular stiffness (Adjusted R2 = 0.046). Together the influencing factors in regard to metabolic syndrome and HbA1c had no significant effect on vascular stiffness (p = 0.584). HbA1c is the influencing factor that has the greatest effect on vascular stiffness. There was a significant correlation between HbA1c and vascular stiffness as measured by baPWV compared with other metabolic syndrome components. The contribution of influencing factors in regard to metabolic syndrome and HbA1c was 4.6% against vascular stiffness. Hemoglobin A1c is the influencing factor that has the greatest effect on vascular stiffness.

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