Fikarini H. Puteri and Jennifer Widjaja and Febriastuti Cahyani and Latief Mooduto and Dian Agustin Wahjuningrum (2019) The Comparative Toxicity of Xanthones and Tannins in Mangosteen (Garcinia mangostana Linn.) Pericarp Extract against BHK‑21 Fibroblast Cell Culture. Contemporary Clinical Dentistry, 10 (2). pp. 319-323. ISSN 09762361

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Abstract

Objective: The objective of this study is to compare the toxicity level of xanthones and tannins derived from mangosteen pericarp extract at specific concentrations against BHK‑21 fibroblast cell cultures. Methods: Mangosteen was extracted using a maceration method with ethanol 96%. Xanthones were isolated from the chloroform extract, whereas tannins were isolated using acetone alcohol and serial diluted to 100% concentration. Toxicity levels were monitored after 24 h using 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyl‑tetrazolium bromide assay technique by ELISA reader at 620 nm. Results: Viable cells of BHK‑21 against xanthone concentration began to decrease (40.24%) at 3.98% xanthones, whereas viable cells of BHK‑21 against tannin concentration began to decrease (68.06%) at 2.2% tannins. Conclusion: It is suggested that tannins were more toxic than the xanthones derived from mangosteen pericarp.

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