Evri Kusumah Ningtyas (2019) Perbedaan Ekspresi Malondialdehid Dan Superoksida Dismutase Pada Pulpa Gigi Setelah Aplikasi Ca(Oh)2 Dan Kombinasi Ekstrak Propolis - Ca(Oh)2. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background : One of the disadvantage of calcium hydroxide (Ca(OH)2) as pulp capping material is it can induce pulp inflammation which last up to 3 months. One of mediator identified during the inflammatory process is free radicals. An increase in oxygen free radicals in the pulp disturbs the defensive function of the pulp like its ability to form reparative dentine. The most predicative markers that often used for oxidative stress are malonaldehyde (MDA) and superoxide dismutase (SOD). Propolis has antioxidant activity that can reduce free radicals. Objective : To determine and compare the expression of MDA and SOD in rat’s dental pulp after capped by Ca(OH)2 and combination of Ca(OH)2 – propolis extract. Method : Thirty Wistar rats were divided randomly into three groups of ten rats each. Group I : control, Group II : Ca(OH)2, Group III : combination of Ca(OH)2 – propolis extract. The rat’s teeth were prepared using low speed round bur until perforated then the capping agent was applied. After 3 and 7 days the rats were sacrificed and processed for histological analysis. Result : There were significant differences of MDA and SOD expression in day 3 and day 7 between Ca(OH)2 – propolis group and Ca(OH)2, and between Ca(OH)2 – propolis group and control group. Conclusion : MDA expression after aplication of combination Ca(OH)2 – propolis extract was smaller and SOD expression after aplication of combination Ca(OH)2 – propolis extract was higher after 3 and 7 days than aplication of Ca(OH)2.

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