EKA PRIA UTAMA MULYANA, 050911200 (2013) SINTESIS 6-[(N,N-DISIKLOHEKSILAMINO)METIL]PINOSTROBIN MELALUI REAKSI MANNICH DENGAN MATERIAL AWAL PINOSTROBIN. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Pinostrobin is one of the flavonoids that have anticancer, antimicrobial, antioxidant, and anti-inflammatory activities. Pinostrobin has a good potential in the development of anticancer drugs. One way to increase the activity of an active compound is by modifying the molecular structure using Mannich reaction. This study aims to obtain 6-[(N,N-dicyclohexylamino)methyl]pinostrobin as the result of Mannich reaction between pinostrobin with formaldehyde and dicyclohexylamine. The reaction itself consists of two steps. Firstly, dicyclohexylamine was reacted with formaldehyde to obtain iminium salt. Shortly afterwards, pinostrobin was reacted with the iminium salt that had been obtained from the first step reaction. The product was then purified by column chromatography to get a yellowish white solid in 2% field after 27 hours of reaction time. Analysis of the resulted product’s structure was carried out using ultraviolet spectrophotometry, infrared spectrophotometry, and 1H-NMR spectrometry, and it was concluded that the obtained compound was 6-[(N,N-dicyclohexylamino)methyl]pinostrobin.

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