RISMA ZAHRA PRIVEA, 051011200 (2013) SINTESIS SENYAWA O-(2-KLOROBENZOIL)ASETAMINOFEN DAN UJI AKTIVITAS ANALGESIK PADA MENCIT (Mus musculus) DENGAN METODE HOT PLATE. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The purposed of this research is to synthesis O-(2- chlorobenzoyl)acetaminophen and to determine its activity analgesic activity in mice (Mus musculus). Firstly compound was tested by in silico assay with Molegro Virtual Docker program. Then, the compound is synthetized by reacting paracetamol with 2-chlorobenzoyl chloride using Schotten-Baumann acylation reaction principle. Yield percentage of this product was 72% and the purity was analyzed by melting point test and thin layer chromatography. The structure of the compound was confirmed by UV-Vis spectrophotometer, infrared spectrophotometer and nuclear magnetic resonance spectrometer. At last, its analgesic activity was assayed by hot plate method at 55 ºC± 0.5ºC before and 30, 60, 90, 120 minutes after oral admistration in mice with dose 100 mg/kg body weight. CMC-Na as control, and paracetamol as reference. The O-(2- chlorobenzoyl)acetaminophen has 37,04% maximum possible effect which shows that it has higher analgesic activity than paracetamol (33,2%).

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