AMALIA ILLIYYIN, 050911250 (2013) PENGARUH ATTAPULGIT TERHADAP ABSORPSI LEVOFLOKSASIN ORAL MENGGUNAKAN DATA PLASMA DARAH KELINCI. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Several important interactions of fluoroquinolones with other drug have been reported in the literature. It was recognized that divalent or trivalent cations such as Ca2+, Mg2+, or aluminium as contained in attapulgit reduce oral absorption of fluoroquinolones by chelation. The effects of 0.7 mL/kg body weight doses of attapulgite on the absorption of oral levofloxacin after a single 23 mg/kg body weight doses were investigated in 5 rabbit subjects, Levofloxacin was administered under three conditions: alone as control, concomitant as group 1, and given two hours following the administration of attapulgite as group 2. The concentration of levofloxacin in plasma were determined by a validated high performance liquid chromatography method. Those parameters included tmax, Cmax, and AUC0- 240 were determinated. In control treatment, the average value of tmax 120 ± 0.00 menit, Cmax 7.99 ± 0.80 μg/ml, dan AUC0-240minutes 1407.06 ± 155.01 μg.minutes/ml.. The effect of administration of levofloxacin with attapulgite immediately decrease of Cmax 54.65 ± 7.51 % and AUC0-240 59.83 ± 4.68 % compared with control. A smaller but have no significant decrease in Cmax 6.70 ± 3.80 % and AUC0-240 14.22 ± 7.62 % was noted on administration of levofloxacin within two hours after attapulgite compared with control. The effect of attapulgite not significant in tmax. According to these results, the administration of levofloxacin and attapulgite should be given lag time at least 2 hours to improve bioavailability of levofloxacin.

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