Cytotoxic Carbazole Alkaloid from the Root of Clausena cxcavata on Hela Cell L

Tin Myo Thant and Nanik Siti Aminah and Alfinda Novi Kristanti and Rico Ramadhan and Hnin Thanda Aung and Yoshiaki Takaya (2019) Cytotoxic Carbazole Alkaloid from the Root of Clausena cxcavata on Hela Cell L. In: Proceedings of the 1st International Conference on Chemical Science and Technology Innovation (ICOCSTI 2019). Department Of Chemistry Universitas Sumatera Utara, Medan. ISBN 978-989-758-415-2,

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Abstract

In a search for bioactive constituents from Myanmar medicinal plants, a carbazole alkaloid, named 7hydroxy heptaphylline (1) was isolated from the root of Clausena excavata. The structure of isolated compound was elucidated based on spectrophotometric data such as UV-vis, FT-IR, NMR and HRMS data. The cytotoxicity of the isolated compound (1) was evaluated by MTT assay against on HeLa cancer cells. The compound (1) exhibited moderate inhibition activity with IC50 41.4 µg/ml.

Item Type: Book Section
Uncontrolled Keywords: Clausena excavata, Carbazole Alkaloid, 7-hydroxylheptaphylline, MTT assay, HeLa.
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: 08. Fakultas Sains dan Teknologi > Kimia
Creators:
CreatorsNIM
Tin Myo ThantUNSPECIFIED
Nanik Siti AminahNIDN0014056707
Alfinda Novi KristantiNIDN0015116702
Rico RamadhanUNSPECIFIED
Hnin Thanda AungUNSPECIFIED
Yoshiaki TakayaUNSPECIFIED
Depositing User: Mr Vega Andi Budiman
Date Deposited: 31 Aug 2020 01:52
Last Modified: 31 Aug 2020 01:52
URI: http://repository.unair.ac.id/id/eprint/98069
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