Paulus Sugianto (2010) Patofisiologi Iskemik Stroke Terkini (Patophysiology Update of Ischemic Stroke). In: Kumpulan Makalah The 12th Continuing Neurological Education (12th CNE). Airlangga University Press, Surabaya, pp. 178-193. ISBN 978-979-1330-82-4

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Abstract

Stroke is a leading cause of disability and health worldwide. Recent data shows that ischaemic stroke is constituting around 80% of all strokes. A better management of stroke can be achieved only if the pathophysiology is properly understood. common conditions associated with ischaemic stroke are trombosis, atherisclerotic proccess, emboli and reducing blood pressure. Appropriate treatment is required as incidence of disability and death are still high. Brain is a small organ with higher consumtion of glucose and oxygen. Failure to provide its need results in permanent damage. This irreversible condition is heralded by depletion of energy metabolites and failure of the cell membrane to maintains its physiologic gradients with dramatic disruption of ion and waterhomeostasis. Atherosclerosis is iniating blood flow disruption, resulting in local reaction and leading to vascular obstruction. This event contributes to inflammatory process, brain oedema, neurond death and penumbra expansion. Understanding of this pathophysiology will reduce incidence of death and disability.

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