Ryan Septa Kurnia and Widjiati and Lilik Maslachah (2015) Pengaruh Pemberian Hematopoietic Stem Cells terhadap Panjang dan Berat Janin pada Mencit (Mus musculus) Bunting yang Diintoksikasi Logam Berat Timbal (Pb). Veterinaria Medika, 8 (1). pp. 87-92. ISSN 1979-1305

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Abstract

The aim of this research was to found the effect of hema topoietic stem cells into changes of pregnant mice fetus body size and weight that intoxicated with lead (Pb) and the correlation between the treatment of transplantation hematopoietic stem cells, intoxication by lead (Pb) and changes of mice (Mus musculus) fetus size and weight as parameters. Twenty mice divided into 5 groups of 4 mice each served as subject for this study. Mice group I (PO) as a control was given 1 ml aquades/day, and group 2 (Pl) were exposed to lead at a dose of 54,425 mg/kg BW, mice group 3 (P2) were exposed to lead at a dose of 40,818 mg/kg BW, other group were exposed to lead with hematopoietic stem cells group 4 (P3) at a dose of 54,425 mg/kg BW + lx105 cells/mL and group 5 (P4) at a dose 40,818 mg/kg BW. All pregnant female were dosed between gesta tion day 6th-till 15th. Twenty mice were sacrificed at gestation day 1ih. Their fetus was taken to measuring crown to rump length and body \Veight of fetus. The data were analyzed by ANO VA n1ethod based on Completely Randomized Design, and further analyzed by Duncan's l0ultiple Range Test. The result from statistical analysis showed that treatment with hematopoietic stem cells increased fetus size and weight of pregnant mice (p<0.05). Other group showed a significant decrease in body size and weight in fetus exposed to lead acetate compared to control. In conclusion, transplantation hematopoietic sten1 cells into pregnant mjce was intoxication by lead (Pb)increased fetus body size and body weight Keywords: Hematopoietic stem cells, lead, size, weight fetus

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