Primandono Perbowo and Brahmana Aksandar (2019) KLK6 as a Predictor of Ovarian Malignancy. Modern Medicine, 26 (4). pp. 189-195. ISSN 2360-2473

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Abstract

Objective: To measure the levels of KLK6 and CA125 tumor marker and compare them as a predictor of epithelial type ovarian malignancy. KLK6 and CA125 were taken from blood serum of 60 ovarian tumor patients who met the inclusion criteria in consecutive sampling. CA125 quantitative examination and KLK6 titer were performed by ELISA. Surgical tissue from Dr. Soetomo Hospital, Surabaya was examined histopathologically at the Anatomical Pathology Laboratory of the Faculty of Medicine Airlangga University, Surabaya. Methods: This study is a diagnostic test using a cross-sectional design with a total sample of 60 ovarian tumor patients from obstetrics and gynecology outpatient clinic, Soetomo Hospital, Obstetrics and Gynecology Department, Faculty of Medicine, Airlangga University, Surabaya. CA125 was examined by ELISA, while KLK6 was examined using an ELISA reagent kit from Enzo Life Sciences Inc., USA. Results: This study examined a total sample of 60 patients, 30 patients (50%) with benign ovarian tumors, 26 patients (43.33%) with stage I ovarian cancer and 4 patients (6.66%) with stage II ovarian cancer. The best cut off for KLK6 is 3.14ng/mL and the standard CA125 cut-off is 35U/mL. The sensitivity and specifi city of Ca125 are 70.00; 33.33, the sensitivity and specifi city of KLK6 are 50.00; 100.00, PPV and NPV of Ca125 are 51.22; 52.63, PPV and NPV of KLK6 are 100.00; 66.67. Conclusion: KLK6 showed high specifi city for the diagnosis of ovarian cancer. This can improve the diagnostic accuracy of Ca125 which has high sensitivity but low specifi city. A combined panel of Ca125 and KLK6 showed high diagnostic effi ciency for early-stage ovarian cancer.

Item Type:	Article
Uncontrolled Keywords:	kallikrein related peptidase 6 (KLK6), ovarian cancer, diagnosis, meta-analysis
Subjects:	R Medicine > R Medicine (General) R Medicine > RG Gynecology and obstetrics > RG1-991 Gynecology and obstetrics
Divisions:	01. Fakultas Kedokteran > Ilmu Kebidanan dan Kandungan
Creators:	Creators NIM Primandono Perbowo NIDN8833800016 Brahmana Aksandar NIDN0014057304
Depositing User:	arys fk
Date Deposited:	09 Sep 2020 01:46
Last Modified:	09 Sep 2020 01:46
URI:	http://repository.unair.ac.id/id/eprint/98648
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