Nunuk Dyah Retno Lastuti and Fedik Abdul Rantam and Poedji Hastutiek and Dony Chrismanto (2017) Protein of Sarcoptes scabiei var.caprae inducing rabbit's immune response and toll-like receptor-2 (TLR-2) as marker. Advances in Health Sciences Research (AHSR), 5. pp. 79-83. ISSN 978-94-6252-481-1

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Abstract

This research aims are to detect S.scabiei var.caprae antigenic protein which can induce cellular immune response in rabbit as acquired immunity with TLR-2 as marker. This research was performed in several stages i.e soluble protein S.scabiei var.caprae mites extraction; rabbit immunization by inoculating protein antigen S. scabiei var. caprae with dosage of 200μg, repeated five times as booster in two weeks; examination of TLR-2 expression using direct immunofluorescence technique. Cellular immune response is shown by TLR-2 expression in rabbit T limphocytes which appear yellow to green fluorescence color using fluorescence microscope. The amount of fluorescence T lymphocytes showed a significant difference (p<0.05) between control and various boosters, and significantly increased in 3rd booster or 42 days post immunization. The antigenic protein of S.scabiei var.caprae contains ligands, which involve in pathogen associated molecular pattern (PAMP) that can induce cellular immune response in rabbit as with TLR- 2 as marker. It shows that TLR-2 is not only involved in innate immunity but also in acquired immunity. Keywords : acquired immunity, goat, Sarcoptes scabiei var.caprae , TLR-2

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