The Active Marker Compound Identification of Artocarpus champeden Spreng, Stembark Extract, MoraCahlcone A As Antimalarial

ACHMAD, FUAD HAFID and NI, PUTU ARIANTARI and LIDYA, TUMEWU and AGRIANA, ROSMALINA HIDAYATI and ATY, WIDYAWARUYANTI (2012) The Active Marker Compound Identification of Artocarpus champeden Spreng, Stembark Extract, MoraCahlcone A As Antimalarial. The Active Marker Compound Identification of Artocarpus champeden Spreng, Stembark Extract, MoraCahlcone A As Antimalarial, 4. pp. 247-249. ISSN 0975 - 1491

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Official URL: https://www.ijppsjournal.com/Vol4Suppl5.htm

Abstract

Artocarpus champeden Spreng. (Moraceae), commonly known as ”cempedak”, has been traditionally used for malarial remedies. Several studies reported that A. champeden Spreng. stembark has in vitro and in vivo antimalarial activity. The main aim of this research was to isolate and identify an active marker compound of A. champeden stembark for quality control purpose of A. champeden stembark extract in the development of this extract as phytomedicine antimalarial product. The isolation method was bioactivity guided column chromatography and preparative TLC techniques. The marker compound that has been isolated showed potent antimalarial activity with an IC50 value of 0.18 μg/ml against Plasmodium falciparum 3D7strain. Based on UV, IR, 1H NMR, 2D NMR (COSY, HMBC and HMQC) spectral and identification of other references, the active marker compound was identical with known prenylated chalcone compound, Morachalcone A.

Item Type: Article
Uncontrolled Keywords: Artocarpus champeden Spreng., Antimalarial, Morachalcone A, Active marker compound
Subjects: Q Science > QK Botany > QK1-989 Botany
R Medicine > R Medicine (General) > R5-920 Medicine (General)
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi > Farmakognosi Fitokimia
Creators:
CreatorsNIM/NIDN
ACHMAD, FUAD HAFIDachmadfuad@ff.unair.ac.id
NI, PUTU ARIANTARIUNSPECIFIED
LIDYA, TUMEWUUNSPECIFIED
AGRIANA, ROSMALINA HIDAYATIUNSPECIFIED
ATY, WIDYAWARUYANTIaty-w@ff.unair.ac.id
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 08 May 2017 21:20
Last Modified: 08 May 2017 21:20
URI: http://repository.unair.ac.id/id/eprint/56514
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