EKSPRESI PROTEIN TELOMERASE DAN CASPASE 3 SEL HIPERPLASIA PARENKIM PARU PADA PEMBERIAN EKSTRAK Andrographis paniculata Ness (Studi pada Tikus Sprague-Dawley dengan Induksi DMBA)

NISMATUN KHAIRAH, 050710019 (2012) EKSPRESI PROTEIN TELOMERASE DAN CASPASE 3 SEL HIPERPLASIA PARENKIM PARU PADA PEMBERIAN EKSTRAK Andrographis paniculata Ness (Studi pada Tikus Sprague-Dawley dengan Induksi DMBA). Skripsi thesis, UNIVERSITAS AIRLANGGA.

[img]
Preview
Text (ABSTRAK)
ABSTRAK.pdf

Download (122kB) | Preview
[img] Text (FULLTEXT)
download.php_id=gdlhub-gdl-s1-2012-khairahnis-18878&no=1
Restricted to Registered users only

Download (1kB) | Request a copy
Official URL: http://lib.unair.ac.id

Abstract

Andrographis paniculata Ness has been known as a medicine for many kind of diseases, one of them is for cancer. To determine the carcinogenesis inhibition effect of A. paniculata extract, it has examined the effect on 7,12- dimethylbenz [a]anthrasene (DMBA)-induced rat lung hyperplasia model in female Sprague-Dawley rats. DMBA 20 mg/kg bw was given twice a week for five weeks by oral. The extract was given in three doses equivalent with andrographolide 10, 30 and 100 mg/kg bw.Carcinogenesis inhibition of A. paniculata extract was evaluated by lung histology that showed decreasing interalveolar septum cells proliferation compared with DMBA group. The role of andrographolide decrease cells proliferation and increase cells apoptosis on lung cancer was evaluated by imunohistochemical methode. Imunohistochemical analysis results that andrographolide can decrease expression of telomerase, an enzyme that contributes to immortality of cells by allowing continued cell proliferation, and increase expression of caspase 3 that considered to be the main executioner caspase in apoptotic process.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF 360 / 11 Kha e
Uncontrolled Keywords: ANDROGRAPHIS PANICULATA; LUNG HYPERPLASIA
Subjects: R Medicine
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
NISMATUN KHAIRAH, 050710019UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorJunaidi Khotib, S.Si., M.Kes., Ph.D., Apt.UNSPECIFIED
Depositing User: Mr Mudjiono Mudj
Date Deposited: 01 Feb 2012 12:00
Last Modified: 15 Aug 2016 02:54
URI: http://repository.unair.ac.id/id/eprint/8991
Sosial Share:

Actions (login required)

View Item View Item