PENGARUH SUHU DAN KELEMBABAN UDARA TERHADAP STABILITAS FISIK KOKRISTAL LORATADIN-ASAM SUKSINAT DENGAN PERBANDINGAN MOLAR 1:1

GRACE CADYTA HANI PUTRI, 051511133106 (2019) PENGARUH SUHU DAN KELEMBABAN UDARA TERHADAP STABILITAS FISIK KOKRISTAL LORATADIN-ASAM SUKSINAT DENGAN PERBANDINGAN MOLAR 1:1. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Loratadin is a second generation of antihistamin that classified as Biopharmaceutical Classification System (BCS) II, which mean loratadin has low solubility and high permeability. Cocrystal is a method that could improve solubility of loratadin which succesfully able to produced using succinic acid as it’s coformer at a molar ratio of 1:1. In previous studies, cocrystal have been shown to be susceptible to dissociation at high humidity and temperature because of bond release of the two component. This study is observed stability of cocrystal at 30oC / 75% RH, 40oC / 75% RH, 30oC / 90% RH, and 40oC /90% RH. Physical characteristics was investigated using Differential Thermal Analysis (DTA) and Powder X-Ray Diffraction (PXRD). Results from DTA and PXRD showed that dissociation of cocrystal susceptible at 40oC and humidity 90%. Thermogram DTA showed addition endothermic peak of the cocrystal component. PXRD spectrum showed different intensity than cocrystal.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F 25/19 Put p
Uncontrolled Keywords: PENGARUH SUHU DAN KELEMBABAN UDARA TERHADAP STABILITAS FISIK KOKRISTAL LORATADIN-ASAM SUKSINAT DENGAN PERBANDINGAN MOLAR 1:1
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
GRACE CADYTA HANI PUTRI, 051511133106UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorProf. Dr. Dwi Setyawan, S.Si., M.Si., Apt, NIDN: '0030117104UNSPECIFIED
Depositing User: Dwi Marina
Date Deposited: 11 Nov 2019 03:11
Last Modified: 11 Nov 2019 03:11
URI: http://repository.unair.ac.id/id/eprint/90655
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