PENGARUH JUMLAH POLIMER EUDRAGIT S100 TERHADAP KARAKTERISTIK FISIK MIKROPARTIKEL RUTIN

HADI NUR ROMADLON, 051511133074 (2019) PENGARUH JUMLAH POLIMER EUDRAGIT S100 TERHADAP KARAKTERISTIK FISIK MIKROPARTIKEL RUTIN. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Rutin had potencial as antioxidant and anti-inflammatory. However, Rutin has limited behavior such as low bioavailability and instability in acidic extreme condition of gastrointestinal tract. Microparticle with eudragit S100 as matrix had been studied to overcome these problem. The objective of this research was to investigate the effect of eudragit S100 concentration on physical characteristics, swelling index, and entrapment efficiency of rutin-eudragit S100 microparticles. Microparticles were prepared with different ratio of rutin and eudragit S100 which were 1:50, 1:60, and 1:70. The result showed that microparticle rutin-eudragit S100 had spherical shape. FTIR spectrum, DTA thermogram, and XRD diffractogram showed the change of rutin crystallinity. Swelling test in HCl solution pH 1,2 result indicated microparticle rutin-eudragit S100 could protect rutin. The entrapment efficiency of microparticle enhanced as eudragit S100’s concentration increase. Microparticle rutin-eudragit S100 showed good results for increasing the stability of rutin in acidic extreme conditions.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F 32/19 Rom p
Uncontrolled Keywords: rutin, eudragit S100, microparticle, physical characteristics, swelling index, entrapment efficiency
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
HADI NUR ROMADLON, 051511133074UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorHelmy Yusuf, S.Si., M.Sc., Ph.D., Apt., NIDN: '0015077901UNSPECIFIED
Depositing User: Dwi Marina
Date Deposited: 11 Nov 2019 04:00
Last Modified: 11 Nov 2019 04:00
URI: http://repository.unair.ac.id/id/eprint/90663
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