Yoshihiko Yano and Takako Utsumi and Maria Inge Lusida and Yoshitake Hayashi (2015) Hepatitis B virus infection in Indonesia. World Journal of Gastroenterology, 21 (38). pp. 10714-10720. ISSN 10079327

	Text (Artikel) Hepatitis B Virus.pdf Download (1MB)
	Text (Peer Review) Hepatitis B Virus.pdf Download (1MB)
	Text (Similarity) Hepatitis B virus infection in Indonesia_2.pdf Download (2MB)

Abstract

Approximately 240 million people are chronically infected with hepatitis B virus (HBV), 75% of whom reside in Asia. Approximately 600000 of infected patients die each year due to HBV-related diseases or hepatocellular carcinoma (HCC). The endemicity of hepatitis surface antigen in Indonesia is intermediate to high with a geographical difference. The risk of HBV infection is high in hemodialysis (HD) patients, men having sex with men, and health care workers. Occult HBV infection has been detected in various groups such as blood donors, HD patients, and HIV-infected individuals and children. The most common HBV subgenotype in Indonesia is B3 followed by C1. Various novel subgenotypes of HBV have been identified throughout Indonesia, with the novel HBV subgenotypes C6-C16 and D6 being successfully isolated. Although a number of HBV subgenotypes have been discovered in Indonesia, genotype-related pathogenicity has not yet been elucidated in detail. Therefore, genotype-related differences in the prognosis of liver disease and their effects on treatments need to be determined. A previous study conducted in Indonesia revealed that hepatic steatosis was associated with disease progression. Pre-S2 mutations and mutations at C1638T and T1753V in HBV/B3 have been associated with advanced liver diseases including HCC. However, drug resistance to lamivudine, which is prominent in Indonesia, remains obscure. Although the number of studies on HBV in Indonesia has been increasing, adequate databases on HBV infection are limited. We herein provided an overview of the epidemiology and clinical characteristics of HBV infection in Indonesia.

Item Type:	Article
Uncontrolled Keywords:	Hepatitis B virus, Epidemiology, Prevention, Clinical characteristics, Indonesia
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Divisions:	01. Fakultas Kedokteran > Mikrobiologi Klinik
Creators:	Creators NIM Yoshihiko Yano UNSPECIFIED Takako Utsumi UNSPECIFIED Maria Inge Lusida NIDN0017095807 Yoshitake Hayashi UNSPECIFIED
Depositing User:	arys fk
Date Deposited:	14 Oct 2020 13:36
Last Modified:	14 Oct 2020 13:36
URI:	http://repository.unair.ac.id/id/eprint/100209
Sosial Share:

Actions (login required)

View Item