Takako Utsumi and Maria Inge Lusida and Zayyin Dinana and Rury Mega Wahyuni and Laura Navika Yamani and Juniastuti and Soetjipto and Chieko Matsui and Lin Deng and Takayuki Abe and Yen Hai Doan and Yoshiki Fujii and Hirokazu Kimura and Kazuhiko Katayama and Ikuo Shoji (2017) Occurrence of norovirus infection in an asymptomatic population in Indonesia. Infection, Genetics and Evolution, 55. pp. 1-7. ISSN 15677257

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Abstract

Norovirus (NoV) is a major cause of nonbacterial acute gastroenteritis worldwide in all age groups, and asymptomatic individuals may contribute to NoV transmission as a reservoir. Nonetheless, little information is available regarding asymptomatic NoV infection in Indonesia. We performed an epidemiological analysis of NoV infection among asymptomatic healthy volunteers in the city of Surabaya, Indonesia (population ~ 2.75 million). A total of 512 stool samples from 18 individuals (age range 20–42 years) collected from July 2015 to June 2016 were examined. The detection of NoV and the genotype classification were carried out by a reverse transcription-polymerase chain reaction (RT-PCR) direct sequencing method. NoV was detected in 14 of the 512 stool samples (2.7%), with 7 individuals (38.9%) having at least 1 positive stool sample. All 14 of the NoV strains detected belonged to genogroup GII. The phylogenetic analysis indicated that 10 strains (71.4%) were grouped with GII.2, 2 (14.3%) were GII.17, 1 was GII.4 Sydney 2012, and 1 was GII.1. The circulation of GII.Pg/GII.1 and GII.Pe/GII.4 Sydney 2012 recombinant variants was detected among an asymptomatic population in Surabaya, Indonesia. Of the 7 positive individuals, 2 were repeatedly infected with the same strain and heterogenous strains. Taken together, our results suggest that the excretion of NoV from healthy individuals is one of the sources of NoV outbreak.

Item Type:	Article
Uncontrolled Keywords:	Asymptomatic, Norovirus, Reinfection, Recombination, Indonesia, Adult
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Divisions:	01. Fakultas Kedokteran > Mikrobiologi Klinik
Creators:	Creators NIM Takako Utsumi UNSPECIFIED Maria Inge Lusida NIDN0017095807 Zayyin Dinana UNSPECIFIED Rury Mega Wahyuni UNSPECIFIED Laura Navika Yamani UNSPECIFIED Juniastuti NIDN0024067104 Soetjipto NIDN0017025004 Chieko Matsui UNSPECIFIED Lin Deng UNSPECIFIED Takayuki Abe UNSPECIFIED Yen Hai Doan UNSPECIFIED Yoshiki Fujii UNSPECIFIED Hirokazu Kimura UNSPECIFIED Kazuhiko Katayama UNSPECIFIED Ikuo Shoji UNSPECIFIED
Depositing User:	arys fk
Date Deposited:	16 Oct 2020 05:54
Last Modified:	16 Oct 2020 05:54
URI:	http://repository.unair.ac.id/id/eprint/100238
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