Budi Suprapti (2013) Variability In Pharmacokinetic Of Amikacin In Open Fracture Orthopaedic-Traumatologic Patients. In: Proceeding The 3rd Inetrnational Conference on Pharmacy and Advanced Pharmaceutical Sciences. Book 2 Clinical Pharmacy (ICPAPS). Faculty of Pharmacy Gadjah Mada University, Yogyakarta, pp. 37-42. ISBN 978-602-1594-02-5

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Abstract

Amikacin is one of aminoglycoside antibiotic group, distributed in extracellular fluids with low plasma protein bound, and eliminated mainly by renal excretion. But it has reported that this drug has great variability in pharmacokinetic and it concentration achievement in the body. Because of its narrow therapeutic index property, it need individually dosing. The aimed of this study is to determine pharmacokinetic parameter of amikacin in adults open fracture orthopaedic surgery patients. Amikacin 500 mg was administered by IV bolus injection, blood samples were drawn 2 times in 1- 8 hours post second injection (post operation). Amikacin in the serum samples assayed by Homogenous Particle-enhanced Turbidimetric Immunoassay (PETIA). Pharmacokinetic parameterization was done by Nonparameteric Expectation Maximization with NPAG-USC*PACK program for elimination rate constant (K) and Volume of distribution (Vd) Parameterization in 15 patients, through joint and marginal density probability function showed there are great variability in pharmacokinetic of amikacin with Vd values 18.213 ± 6.355 liter (range 10,693 - 31,942 liter), K values 0.343 ± 0.108 hours'1 (range 0.107 - 0.514 hours'1). This results showed giving amikacin individually in this patients group is needed. Key words: aminoglycoside, amikacin, pharmacokinetic, vaiability, open fracture,orthopaedic-traumatology.

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