Tisya Yumn Al-Zuhroh (2020) Pengaruh Pemberian Ekstrak Methanol 95% Kopi Robusta (Coffea canephora) Terhadap Gambaran Histologis Hepar Mencit (Mus musculus) Yang Diinduksi MSG (Monosodium Glutamate). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

MSG (Monosodium Glutamate) is a food additive in the form of L-glutamic acid that has been used in vurious products, which used for arising umami taste. Excessive consumption of MSG can cause an imbalance between antioxidants and ROS, resulting in oxidative stress, and it has negative effect on liver. Coffee is a plant that contains high antioxidant compounds, namely chlorogenic acid which can function as a hepatoprotector. This study aims to analyze the effect of 95% methanol robusta coffee extract on histological of mice (Mus musculus) liver induced with MSG (Monosodium Glutamate). This study was completely randomized design (CRD), using 20 male mice for 5 treatment groups: K+ (MSG 0.12 mg and Vitamin C 6 mg), K- (MSG 0.12 mg and CMC Na 0.1 ml), P1 (MSG 0.12 mg and RCE 0.1 mg), P2 (MSG 0.12 mg and RCE 0.2 mg), and P3 (MSG 0.12 mg and RCE 0.4 mg) orally for 42 days. Histopathological scores were analyzed with Saphiro-Wilk, Levene, and Kruskal Wallis test. The results of Saphiro Wilk and Levene test obtained P<0.05, and on Kruskal Wallis test obtained P=0,391 which indicates that the data was not significant (P>0.05). In addition the control and treatment groups there were not significant. This study conclude that 95% methanol robusta coffee extract did not have significant effect on liver cell.

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