RETNO PARWATI, 050911247 (2016) MODIFIKASI MOLEKUL p-AMINOFENOL MENJADI N-m-KLOROBENZOIL-p-AMINOFENOL DAN UJI AKTIVITAS ANALGESIK DENGAN MENCIT (Mus muscullus). Skripsi thesis, UNIVERSITAS AIRLANGGA.
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Abstract
To develop new drug in analgesic-antipyretic class we had modified paminofenol to produce N-m-chlorobenzoyl-p-aminophenol. The objective of the research is to produce N-m-chlorobenzoyl-p-aminophenol and examine its analgesic activity. The compound was produced by reacting p-aminofenol and mchlorobenzoyl chloride using solvent-modified Schotten-Baumann method. The analgesic activity was examined by writhing test. The synthesis product has melting point 210-212 oC and 41% yield. The compound was confirmed as N-m-chlorobenzoyl-p-aminophenol base on spectroscopic data IR and 1H-NMR. The ED50 of synthetic compound was 26 mg/kg body-weigh, while paracetamol has ED50 45 mg/kg body-weigh. It concluded that N-m-chlorobenzoyl-p-aminophenol had analgesic activity higher than paracetamol.
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKB KK-2 FF.KF.34/15 Par m | |||||||||
| Uncontrolled Keywords: | N-M-CHLOROBENZOYL-P-AMINOPHENOL; ANALGESIC ACTIVITY | |||||||||
| Subjects: | R Medicine R Medicine > R Medicine (General) > R5-130.5 General works |
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| Divisions: | 05. Fakultas Farmasi | |||||||||
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| Depositing User: | Nn Deby Felnia | |||||||||
| Date Deposited: | 24 Feb 2016 12:00 | |||||||||
| Last Modified: | 24 Oct 2016 19:10 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/10285 | |||||||||
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