DEVAKI GANAIDU, 051011275 (2016) KAJIAN EFEKTIVITAS PENGGUNAAN FENITOIN, KARBAMAZEPIN, DAN ASAM VALPROAT TUNGGAL TERHADAP OUTCOME PASIEN EPILEPSI SIMPTOMATIK: Penelitian Dilakukan di Poli Saraf IRJ Saraf RSU Dr. Soetomo Surabaya. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Epilepsy symptomatic is a central nervous system disorder which distributed throughout the world caused by several conditions such as idiopathic, cryptogenic, and symptomatic that effects the brain. Objective of this study is to review clinical data pertinent to the effectiveness of anti-epileptic drugs (AEDs) phenytoin, carbamazepine and valproic acid as monotherapy for symptomatic epilepsy.Method used are randomised controlled trials in adults with symptomatic epilepsy with a comparison of monotherapy phenytoin, carbamazepin and phenytoin. The research was done by observational along with retrospective datas are obtained from medical record documents from the period of 1st April until 30th April. The assessment of this outcome in symptomatic epilepsy patients is seizure-free period from the effectiveness of anti-epileptic drugs (AED). The results of the analysis showed that from 63 patients with type of symptomatic epilepsy, 46,03% diagnosed as epilepsy Unclassified Seizure, 36,51% epilepsy Focal Secondary Generalized Seizure, 15,87% epilepsy Partial Complex Seizure and 1,59% with General Seizure. AEDs which has been used most is phenytoin 46,04% while 26,98% use of carbamazepine and valproic acid. From the results of the analysis indicates the type of epilepsy with seizures found no difference in outcomes in patients given a single AEDs therapy that is phenytoin, carbamazepine and valproic acid were statistically of each value (p> 0.05). The conclusion of the study is the use of Phenytoin, Carbamazepine and Valproate acid used in accordance with the guidelines of the hospital which is influenced by the type of seizure against seizure-free period in patients with symptomatic epilepsy.

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