Citra Dwi Novastuti (2020) Pengaruh Deviasi Septum Nasi Terhadap Waktu Transpor Mukosiliar Dan Histologi Mukosa Kavum Nasi. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Objective : Deviation of the nasal septum causes nasal constriction and influences the inflammation process in the nasal cavity. The increased of mucociliary transport time is the onset of the inflammatory process and indicated by histological changes on both sides of the nasal mucosa. Nasal septum deviation causes chronic mucosal inflammation and squamous cell metaplasia which is prone to cause chronic rhinosinusitis (CRS). Methods : Research conducted at Outpatient Unit Division of Rhinology and Plastic- Maxillofacial Reconstruction of Otorhinolaryngology Head and Neck Surgery Dr. Soetomo General Hospital Surabaya in September to November 2019. The research conducted was observational analytic with cross sectional approach and obtained 10 samples. All study samples underwent examination of mucociliary transport time and histological examination of septoplasty and conchotomy tissue operations. Analysis of the effect nasal septum deviation on mucociliary transport time using paired samples t-test and the effect on histology of the nasal mucosa using Wilcoxon signed ranks test. Result : The mean of mucociliary transport time of the ipsilateral side was 16.156 (SD ±0.545) while the contralateral side was longer at 16.384 (SD ±0.4429). Statistical test on mucociliary transport time obtained p value 0.262. Statistical tests comparing the level of lymphocyte counts between the ipsilateral and contralateral side of deviation showed p value 0.317. Statistical test comparing the occurrence of squamous cell metaplasia found p value 0.317 on the ipsilateral side and 1.0 on the contralateral side. Conclusion : Nasal septum deviation affects the mucociliary transport time and histology of the nasal mucosa. Deviation of the nasal septum affects the level of lymphocyte infiltration on the nasal mucosa on both sides, however there was no effect on the occurrence of squamous cell metaplasia on the nasal mucosa.

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