Anti-inflammatory effect of date seeds (Phoenix dactylifera L) on carrageenan-induced edema in rats

Saryono, S. and Warsinah, W. and Isworo, A. and Ferry Efendi (2018) Anti-inflammatory effect of date seeds (Phoenix dactylifera L) on carrageenan-induced edema in rats. Tropical Journal of Pharmaceutical Research, 17 (12). pp. 2455-2461.

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Abstract

Purpose: To study the anti-inflammatory properties and mechanism of action of date seed extract in carrageenan-induced edema in rats. Methods: In this study with a pre-and post-test control group design, 30 Wistar rats were divided into six groups: Groups C1, C2, and C3 (given 1, 3, and 5 g/kg of soaked date seeds, respectively); positive control (PC, positive control given dexamethasone, 0.5 mg/kg dose), negative control (NC, edema induced by carrageenan), and healthy control (HC, no treatment). In groups C1�3, PC, and NC, carrageenan was administered intraperitoneally prior to date seed, PC and NC treatments. Prostaglandin E2 (PGE-2), cyclooxygenase (COX)-1, COX-2, interleukin (IL)-1β, and IL-12 were measured before and immdiate;y after treatment and compared between the groups. Results: Steeped date seed modulated inflammatory mediators by decreasing IL-1β, COX-1, COX-2, IL-12, and PGE-2 significantly (p < 0.05). Its indicated that the steeped date seeds down-regulate pro-inflammatory mediators in a manner similar to that of dexamethasone as positive control. Conclusion: Steeped date seeds possess anti-inflammatory activity similar to that of dexamethasone, through a mechanism involving decreases in pro-inflammatory mediators. Thus, date seeds is a potential source of herbal anti-inflammatory therapy. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria.

Item Type: Article
Additional Information: cited By 5
Uncontrolled Keywords: cyclooxygenase 1; cyclooxygenase 2; date seed extract; dexamethasone; flavonoid; interleukin 12; interleukin 1beta; plant extract; polyphenol; prostaglandin E2; saponin; terpenoid; unclassified drug, animal experiment; antiinflammatory activity; Article; carrageenan-induced paw edema; controlled study; date (fruit); down regulation; drug screening; enzyme activity; enzyme linked immunosorbent assay; inflammation; male; multiple cycle treatment; nonhuman; phytochemistry; rat
Divisions: Artikel Ilmiah > SCOPUS INDEXED JOURNAL
Creators:
CreatorsNIM
Saryono, S.UNSPECIFIED
Warsinah, W.UNSPECIFIED
Isworo, A.UNSPECIFIED
Ferry EfendiUNSPECIFIED
Depositing User: Ika Rudianto
Last Modified: 03 Feb 2021 05:34
URI: http://repository.unair.ac.id/id/eprint/103557
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