Nurwasis and Rina Wulandari and Delfitri Lutfi (2020) The Effect of topical medication containing benzalkonium chloride on ocular surface disease in glaucoma patients. International Journal of Psychosocial Rehabilitation, 24 (2). pp. 4049-4053. ISSN 14757192

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Abstract

Background, The main cause of the emergence of dry eye and ocular surface disease (OSD) is strongly suspected due to the preservative component of topical medication in the form of benzalkonium chloride(BAK).Various complaints such as uncomfortable, teary, redness, burning and foreign object sensation, glare, often blinking and intermittent blurred vision has-been reported as part of OSD. Objective: The study aimed to investigate the effect of topical medication containing BAK on ocular OSD in glaucoma patients Method: Subject who has been using topical antiglaucomatous medication containing BAK and artificial tears were examined for tear film break up time (TBUT), S I test and corneal staining. Sucject were allowed to close the eyes, then positioned in front of the slit-lamp biomicroscope. Regression test was used to analyze the correlation between each variable. Result: TBUT and S I test were decreased, and corneal staining score was increased, furthermore, BAK is significantly correlated with all of the examination result by using regression test. The effect of the amount and duration of BAK used is significantly correlated with TBUT (p = 0.004). The effect of the amount and duration of BAK used insignificantly correlated with S I test (p = 0.043). This study also has R value as 0.901; >0.05, shows the amount and duration of BAK used is strongly affect TBUT, S I test and corneal staining score. Conclusion: BAK has strong correlation on the event of ocular surface disease.

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