Maria Ulfa (2020) Analisis Efek Samping Etionamid Pada Pasien TB RO Dengan Terapi Jangka Pendek Dan Terapi Individual (Penelitian dilaksanakan di Poli Rawat Jalan TB MDR RSUD Dr. Soetomo Surabaya). Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Ethionamide is one of the anti-tuberculosis drugs that must be present in combination with short-term therapy. Ethionamide is known to cause side effects on the thyroid gland in the form of hypothyroidism and subclinical hypothyroidism. Hypothyroidism often presents with subclinical manifestations that are often masked by other conditions such as arthralgia, depression, ectodermal dysplasia, and ultimately undiagnosed psychosis. This study aimed to analyze the profile of thyroid function and the time it takes to increase serum TSH after ethionamide administration and the associated risk factors. The data were collected retrospectively by using the medical records of MDR TB patients who received ethionamide at the MDR TB Outpatient Polyclinic at Dr. Soetomo Surabaya. There were 51 medical records that met the inclusion criteria, and 3 medical records that met the exclusion criteria because the TSH serum measurement data was not done while the patient was still receiving ethionamide. So that the total sample obtained 48 patient medical records. The results showed that only 1 patient with hypothyroid side effects received an individual therapy containing ethionamide with PAS and 4 patients developed subclinical hypothyroidism. Of the four patients developed subclinical hypothyroidism, 1 patient received an individual therapy containing ethionamide with PAS, 1 patient received an ethionamide-only in individual therapy and 2 patients received short-term therapy. There was 1 DM patient who received an individual therapy containing ethionamide with PAS and developed subclinical hypothyroidism. Management of side effects to overcome side effects is in accordance with the guidelines for TB RO from the Indonesian Ministry of Health 2019.

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