Putri Ramadhani (2021) Scoping Review : Efek Probiotik Terhadap Sistem Imun Pada Pasien Luka Bakar. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

BACKGROUND: One of the problems with burn patients is the impairment of host immunity, which makes difficult to treat. Probiotics that have been widely used related to inflammatory diseases of the gastrointestinal tract also have the effect of modulating the immune system. However, various clinical trials have shown varied results and there is no specific consensus regarding the use of probiotics against the immune system in burns. OBJECTIVE: This aims to explore literature about the effects of probiotics against immune system in burn patients and to identify gaps in the existing literature. METHOD: We conducted a scoping review to examine the literature on the effect of probiotics for immune system in burn patients based on the evaluation of clinical, laboratory, immunohistochemical and microbiological parameters. We searched for peer-reviewed research articles and abstracts in PubMed, ScienceDirect, Scopus, Cochrane, EBSCO/CINAHL and other databases for grey literature, with time limits performed on June 2005 until September 2020, using search terms with database-appropriate keywords. RESULTS AND CONCLUSIONS: We identified 901 articles, of these, 10 articles met inclusion criteria. In this Scoping Review, the proportion of probiotic combination types mostly used multi-strain probiotic combinations. The frequency and types of probiotic strains most often and widely used were Lactobacillus spp (58%), Bifidobacterium spp. (26%), and Streptococcus spp. (16%). Then, the most concentration of oral probiotics route used were in the total probiotic cell content of 109 CFU (42%). The duration of probiotic administration mostly used was 14 days (50%). Meanwhile, the initiated dose of probiotics mostly used on day 4 (50%), respectively. In this Scoping Review, we conclude that the use of probiotics in burn patients has been shown to increase the immune system in burns based on scientific evidence proven by laboratory/immunohistochemical outcome parameters (such as increased secretion of Immunoglobulin A / sIgA, decreased serum CRP, IL-6, leukocytes, neutrophils and lymphocytes), and other clinical outcome parameters (improvement of gastrointestinal balance disorders, decreased mortality, decreased risk of SIRS / sepsis, and shortened Length of Stay). To be able to perform the modulation of the immune system, the optimal dose, strain and duration of probiotic administration has not been established or still vary widely, especially in conditions of severe burns. Therefore, there is a need for further research and more randomized clinical studies using placebo or controls to minimize the risk of bias and better validity regarding the evidence of effectiveness and safety at various degrees of burns.

Item Type:	Thesis (Thesis)
Additional Information:	KKC KK TFK.05-21 Ram s
Uncontrolled Keywords:	Probiotics, Lactobacillus, Bifidobacteria, Monostrain, Multistrain, Immune response, Burns.
Subjects:	R Medicine > RA Public aspects of medicine > RA1-1270 Public aspects of medicine > RA421-790.95 Public health. Hygiene. Preventive medicine > RA638 Immunity and immunization in relation to public health
Divisions:	05. Fakultas Farmasi > Farmasi Klinis
Creators:	Creators NIM Putri Ramadhani NIM051815153002
Contributors:	Contribution Name NIDN / NIDK Thesis advisor Suharjono, - NIDN0022125205 Thesis advisor Iswinarno Doso Saputro, - NIDN8839700016 Thesis advisor Ria Fitrah Arfiani, - -
Depositing User:	Fahimatun Nafisa Nafisa
Date Deposited:	08 Apr 2021 04:48
Last Modified:	08 Apr 2021 04:48
URI:	http://repository.unair.ac.id/id/eprint/105378
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