Two novel coumarins bearing an acetophenone derivative from the leaves of Melicope Quercifolia Repository

Two novel coumarins bearing an acetophenone derivative from the leaves of Melicope Quercifolia

Ratih Dewi Saputri and Tjitjik Srie Tjahjandarie and Mulyadi Tanjung (2021) Two novel coumarins bearing an acetophenone derivative from the leaves of Melicope Quercifolia. Natural Product Research, 35 (8). pp. 1256-1261. ISSN 1478-6419, Online. 1478-6427

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Official URL: https://www.tandfonline.com/doi/full/10.1080/14786...

Abstract

Meliquercifolins A (1), and B (2), two new coumarins are bearing an acetophenone derivative were isolated from the leaves of Melicope quercifolia along with three known compounds, melicodenines E (3), F (4) and I (5). Structures of two new compounds were identified based on spectroscopic analyses (UV, HR-ESI-MS, 1 D and 2 D NMR). Cytotoxic activities of compounds (1–5) towards three human cancer cells (HeLa, MCF-7, P-388), compounds 1, 4 and 5 showed very potent activity against Hela cells with IC50 values 2.6; 0.8; 1.1 μM, respectively.

Item Type:

Article

Uncontrolled Keywords:

Cytotoxicity, Melicope quercifolia, Meliquercifolins A and B

Subjects:

Q Science > Q Science (General)
Q Science > QD Chemistry

Divisions:

08. Fakultas Sains dan Teknologi > Kimia

Creators: