Brahmana Askandar and Lulus Handayani and M. Dimas Abdi Putra (2020) Outcome and Radiotherapy Side Effects of High-Risk Endometrial Cancer. Systematic Review Pharmacy, 11 (5). pp. 192-198. ISSN 0976-2779
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Abstract
The endometrial cancer is radiosensitive. Adjuvant radiotherapy is previously said that it may improve survival rate of high-risk endometrial cancer and decrease recurrences rate. This study evaluated overall survival, disease-free survival (DFS) in high risk endometrial cancer, and postradiotherapy side effects. Analytic retrospective research using medical record was conducted. During the 2013-2018 period there were 185 patients with endometrial cancer undergoing radiotherapy. Prognostic factors for OS which are statistically significant were age, BMI, LVSI, stage, waiting time interval, and recurrence. The prognostic factor group of age >60 years significantly had OS (p = 0.04) and DFS-3 years (p = 0.03) which was better than that of the age group <60 years. Obese patients had OS 77% better than the non-obese group (p = 0.02). The LVSI positive group significantly had OS 0% with OR of 0.3 (95% CI 0.1-0.8) (p = 0.02) and DFS-3 years 50% (p = 0.004). Patients with waiting time intervals (queue) >9 weeks had OS 35% (p = 0.03) with OR of 3.2 (95% CI 1.1-8.8), and lower DFS-3 years (76% vs 91%; p = 0.03). Combination of radiotherapy modalities caused 61% of side effects, but statistically not significant. OS and DFS-3 years in patients >60 years old and obese were better than <60 years of age and non-obese. Positive LVSI group had poorer OS and DFS-3 years. The more side effects were due to the combination of modality.
| Item Type: | Article | ||||||||
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| Uncontrolled Keywords: | endometrium, high risk, radiotherapy | ||||||||
| Subjects: | R Medicine > R Medicine (General) R Medicine > RG Gynecology and obstetrics |
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| Divisions: | 01. Fakultas Kedokteran > Ilmu Kebidanan dan Kandungan Artikel Ilmiah > SCOPUS INDEXED JOURNAL |
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| Depositing User: | arys fk | ||||||||
| Date Deposited: | 11 Jun 2021 03:06 | ||||||||
| Last Modified: | 11 Jun 2021 03:06 | ||||||||
| URI: | http://repository.unair.ac.id/id/eprint/107637 | ||||||||
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