Tutik Sri Wahyuni and Dzul Azmi and Adita Ayu Permanasari and Myrna Adianti and Lidya Tumewu and Tri Widiandani and Chie Aoki Utsubo and Aty Widyawaruyanti and Achmad Fuad Hafid and Hak Hotta (2019) Anti-Viral Activity of Phyllanthus niruri Against Hepatitis C Virus. Malaysian Applied Biology, 48 (3). pp. 105-111. ISSN 0126-8643

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Abstract

Hepatitis C virus (HCV) infection is a global problem that causes liver disease and hepatocellular carcinoma. Although the current standard treatment provided a significant improvement on response rate with sustain virology response more than 90%, however, the high cost was remaining limited access to this therapy, resistance emergence and serious side effects which provide the necessities to find the new anti-HCV agents. The current study, we evaluated the ethanol extract of Phyllanthus niruri for its anti-HCV activities. Anti-HCV activity was determined by in vitro culture cells of Huh 7it. Anti-HCV activity of P. niruri extract revealed strong inhibition against HCV with IC50 values of 4.14 ?g/mL and yield stronger activity in the entry step of the HCV life cycle. Moreover, the P. niruri extract enhanced anti-HCV activity of simeprevir (NS3 protease inhibitor) with increase the activity up to 4-fold compared to a single treatment of simeprevir. Docking analysis was performed to predict the interaction phyllanthin and hypophyllantin, known compounds of P. niruri against HCV receptor. Both of phyllantin and hypophyllantin were mediated a strong interaction with 4GAG, a protein that involved in entry step of HCV. These results suggested that the ethanol extract of P. niruri may be good candidates for the development of anti-HCV drugs.

Item Type:	Article
Uncontrolled Keywords:	Hepatitis C virus, antiviral activity, Phyllanthus niruri, entry step
Subjects:	R Medicine R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions:	05. Fakultas Farmasi
Creators:	Creators NIM Tutik Sri Wahyuni NIDN0025107704 Dzul Azmi UNSPECIFIED Adita Ayu Permanasari UNSPECIFIED Myrna Adianti UNSPECIFIED Lidya Tumewu UNSPECIFIED Tri Widiandani NIDN0004128001 Chie Aoki Utsubo UNSPECIFIED Aty Widyawaruyanti NIDN0026046210 Achmad Fuad Hafid NIDN0012125207 Hak Hotta UNSPECIFIED
Depositing User:	Mr M. Fuad Sofyan
Date Deposited:	15 Jul 2021 01:55
Last Modified:	15 Jul 2021 01:55
URI:	http://repository.unair.ac.id/id/eprint/108084
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