Muhammad Miftahussurur and Langgeng Agung Waskito and Hashem B El-Serag and Nadim J. Ajami and Iswan Abbas Nusi and Ari Fahrial Syam and Takashi Matsumoto and Yudith Annisa Ayu Rezkitha and Dalla Doohan and Kartika Afrida Fauzia and Ummi Maimunah and Titong Sugihartono and Tomohisa Uchida and Yoshio Yamaoka (2020) Gastric microbiota and Helicobacter pylori in Indonesian population. Helicobacter, 25 (4). pp. 1-10. ISSN 10834389

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Abstract

Background The profile of gastric mucosal microbiota has not yet been described in the Indonesian population where the prevalence of Helicobacter pylori is low. Methods This is a cross-sectional study analyzing 16S rRNA of 137 gastric biopsy specimens. We analyzed the association between gastric microbiota, H. pylori infection, and gastric mucosal damage. Result Among 137 analyzed samples, 27 were H. pylori-positive and 110 were H. pylori -negative based on culture, histology, and 16S rRNA gene analysis. Significantly lower α-diversity parameters, including Pielou's index, was observed in H. pylori-infected individuals compared with noninfected individuals (all P < .001). Among H. pylori-negative individuals, the permutational analysis of variance of Bray-Curtis dissimilarity distances showed a significant association with different ethnicities, suggesting some ethnic groups had specific microbiota profiles based on the presence of different operational taxonomic units. The linear discriminant analysis effect size (LEfSe) of the H. pylori-negative group showed significant associations between the presence of Micrococcus luteus and Sphingomonas yabuuchiae with Timor and Papuan ethnicities, respectively. The presence of Bulledia sp and Atopobium sp was associated with the Javanese ethnicity. We observed lower α-diversity scores in individuals with gastric mucosal damage and profiles with high abundances of Paludibacter sp and Dialister sp based on LEfSe analysis. Conclusion Our findings suggest the presence of H. pylori is more correlated with a distinct microbiome profile than ethnic precedence.

Item Type:	Article
Uncontrolled Keywords:	Helicobacter pylori, Indonesia, Microbiome
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Divisions:	01. Fakultas Kedokteran > Ilmu Penyakit Dalam
Creators:	Creators NIM Muhammad Miftahussurur NIDN0029097909 Langgeng Agung Waskito UNSPECIFIED Hashem B El-Serag UNSPECIFIED Nadim J. Ajami UNSPECIFIED Iswan Abbas Nusi NIDN0028025003 Ari Fahrial Syam UNSPECIFIED Takashi Matsumoto UNSPECIFIED Yudith Annisa Ayu Rezkitha UNSPECIFIED Dalla Doohan UNSPECIFIED Kartika Afrida Fauzia UNSPECIFIED Ummi Maimunah NIDN8896900016 Titong Sugihartono NIDN8836800016 Tomohisa Uchida UNSPECIFIED Yoshio Yamaoka UNSPECIFIED
Depositing User:	arys fk
Date Deposited:	12 Jul 2021 03:48
Last Modified:	12 Jul 2021 03:48
URI:	http://repository.unair.ac.id/id/eprint/108522
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