The Role of Testosterone on Sex Dysfunction in T2DM Repository

The Role of Testosterone on Sex Dysfunction in T2DM

Sony Wibisono (2012) The Role of Testosterone on Sex Dysfunction in T2DM. In: Proceeding Joint Symposium. Pusat Diabetes dan Nutrisi RSUD Dr. Soetomo, Surabaya, Surabaya, pp. 165-171. ISBN 978-602-95712-5-7

	Text (Artikel) C-39_compressed.pdf Download (1MB)
	Text (Peer Review) C-39 KADEP.pdf Download (2MB)

Abstract

Testosterone plays a significant role in glucose and lipid metabolism. Metabolic syndrome is clustering of risk factors predisposing to diabetes mellitus type 2, atherosclerosis and cardiovascular morbidity and mortality. The main component of metabolic syndrome are insulin resistance, visceral obesity, glucose tolerance, dyslipidemia, hypertension, and pro inflammation or prothrombotic state. Epidemiology studies showed a direct correlation plasma testosterone and insulin sensitivity and low testosterone increased risk of T2DM. Insulin resistance could diminish release GnRH due to insulin and the GnRH decrease, gonadotropin secreation low, sel Leydic testosterone secretion low. Besides above in visceral obesity cause aromatase increased. HPA axis decreased, inflammation in insulin resistance. That multi factors can decrease testosterone secreation by leydic cell. In men with T2DM have low testosterone is associated with a high prevalence of symptomatic hypogonadism, frequently due to hypogonadotrophic hypogonadism. Between 55 and 58% of our diabetic men with ED had low testosterone levels. This represents a much higer prevalence than that seen in normal men with ED. As previously mentioned, about 35% of men with ED have been reported to have reduced or border-line low androgen levels. The findings of ourselves and others, especially in light of the effect of testosterone levels should be assessed in type 2 diabetic men with ED. Sexual dysfunction is one of Symptom of hypogonadotrophic hypogonadism. Testosterone replacement in hypogonadal men with T2DM and or Metabolic syndrome in TIMES 2 study was associated with beneficial effect in not only sexual health but also insulin resistance, and lipid profiles.

Item Type:

Book Section

Uncontrolled Keywords:

testosterone, metabolism, diabetes mellitus

Subjects:

R Medicine > R Medicine (General)
R Medicine > RC Internal medicine

Divisions:

01. Fakultas Kedokteran > Ilmu Penyakit Dalam

Creators: