Frida Magdalena (2015) Pengaruh pH Terhadap Koefisien Partisi Salisilamid. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The aim of this study was to determine the influence of pH on salicylamide partition coefficient using octanol/buffer within various range of pH (2.0; 3.0; 4.0; 5.0; 6.0; 7.0; 8.0; 9.0; and 10.0). The value of partition coefficient from this study were expected to add information about the characteristics of salicylamide physicochemical, so could be estimated its ability to penetrate biological membranes and its distribution in the body tissues, and could be used for the development of formulation of pharmaceutical preparations which satisfies the requirements of pharmaceutic. The value of the logarithm partition coefficient (P) of salicylamide at pH 2.0; 3.0; 4.0; 5.0; 6.0; 7.0; 8.0; 9.0; and 10.0 respectively was 1.06; 1.06; 1.05; 1.04; 1.04; 0.84; 0.75; -0.35; and -0.68. Results were statistically using one-way anova with degree of convidence 95% or (α) = 0.05. Research results revealed that increased pH from 2.0 up to 10.0 causing a decrease in the value of the logarithm partition coefficient (P) of salicylamide in octanol/buffer. Logarithm partition coefficient (P) not only influenced by pH, but also logarithm partition coefficient of gastrointestinal tract and skin. So, there is suggestion to have research about the influence of logarithm partition coefficient of gastrointestinal tract and skin on salicylamide coefficient partition, in order to have consideration data in formulation salicylamide.

Item Type:	Thesis (Skripsi)
Additional Information:	KKB KK-2 FF F 17 15 Mag p
Uncontrolled Keywords:	Salicylamide, Octanol/Buffer, Ph, Partition Coefficient.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	05. Fakultas Farmasi > Farmastika
Creators:	Creators NIM Frida Magdalena NIM051111019
Contributors:	Contribution Name NIDN / NIDK Thesis advisor Dewi Isadiartuti NIDN0020056509 Thesis advisor Esti Hendradi NIDN0014115703
Depositing User:	Turwulandari
Date Deposited:	12 Feb 2016 12:00
Last Modified:	21 Apr 2020 13:42
URI:	http://repository.unair.ac.id/id/eprint/10920
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