Hendrik Setia Budi, - and Pratiwi Soesilawati, - and Zhafirah Imanina, - (2017) Gambaran histopatologi penyembuhkan luka pencabutan gigi pada makrofag dan neovaskular dengan pemberian getah batang pisang ambon. Majalah Kedokteran Gigi Indonesia, 3 (3). pp. 121-127. ISSN 2442-2576

	Text (ARTIKEL) Gambaran histopatologi penyembuhkan.pdf Download (802kB)
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Abstract

Tooth extraction healing on macrophages and neovascular histopathology induced by ambonese banana stem sap gel. Blood clotting is very important in the early wound healing process. Blood clots will soon be filled with a connective tissue due to the induction of growth factors as granulation tissue. The expression of platelet derived growth factors (PDGF)-BB using the Ambonese banana stem sap gel (Musa paradisiaca var. sapientum) can increase the proliferation of fibroblasts. Macrophages and neovascular support in the early phase of healing. The purpose of this research was to demonstrate that Ambonese banana stem sap gel (GEGPA) can improve the macrophages and neovascular in the socket wound healing. Thirty six wistar rats were used and divided into 3 groups. The mandibular left incisor was extracted. The first group as control was given HPMC 4% gel on socket, the second group was given GEGPA 60%, and third group was given gelatin sponge. Rats were sacrificed on day 3 and 5 for histopathology examination of neovaskular and macrophages on the socket. The results showed that there was significantly different in the control group on a number of neovascular and macrophages in socket on day 3 (p<0.05). No significant difference on day 5 in all groups of neovascular and macrophages number (p>0.05). It was concluded that the use of GEGPA 60% accelerated the wound healing of tooth extraction socket by means of macrophages and neovascular increasing.

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