A Novel Pleiotropic Effect of Beta-Blockers: Useful or Not? Repository

A Novel Pleiotropic Effect of Beta-Blockers: Useful or Not?

Tara Mandiricha, - and Maftuchah Rochmanti, - (2020) A Novel Pleiotropic Effect of Beta-Blockers: Useful or Not? Systematic Reviews in Pharmacy, 11 (9). pp. 178-186. ISSN 09758453

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Official URL: https://www.sysrevpharm.org/abstract/a-novel-pleio...

Abstract

β-adrenergic blockers or β-blockers (BBs) have been the antihypertensive treatment for the past 50 years. Several studies were developed to further explore the therapeutic effects of BB, ranging from use in liver cirrhosis with esophageal varices to involvement in cancer treatment. The Autonomic nervous system (ANS) dysfunction has been shown to cause several of these diseases. Immune suppression, cardiovascular dysfunction, hypertension, and even worse prognosis in cancer patients are due to chronic activation of the sympathetic nervous system (SNS). Based on its mechanism of action, the use of BB drugs has different therapeutic targets, and each has different advantages and side effects. Since the discovery of a new third-generation BB drug that has a complete combination of action, several diseases have hopes of being treated with this agent. Improving survival, hospital discharge, and quality of life affecting patients is the goal of the new therapeutic approach.

Item Type:

Article

Uncontrolled Keywords:

β-blockers, antihypertensive, cardiovascular, esophageal varices, cancer

Subjects:

R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology

Divisions:

01. Fakultas Kedokteran > Farmakologi

Creators: