Hypolipidemic Effects of Rosa Damascena Mill. Extract in Streptozotocin-induced Diabetic Rats Repository

Hypolipidemic Effects of Rosa Damascena Mill. Extract in Streptozotocin-induced Diabetic Rats

Tamam Jauhar, - and Bilqis Inayatillah, - and Maftuchah Rochmanti, - and Achmad Basori, - (2021) Hypolipidemic Effects of Rosa Damascena Mill. Extract in Streptozotocin-induced Diabetic Rats. Indian Journal of Forensic Medicine & Toxicology, 15 (2). pp. 1065-1070. ISSN 0973-9122

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Abstract

Background: Diabetes mellitus is a chronic hyperglycemic condition with a lot of complication which can lead to death. Vascular complication in diabetes commonly caused by dyslipidemia which characterized by decreased HDL, elevated LDL, Cholesterol and Triglyceride. Rosa damascena- an ornamental plantthoughts to have anti hyperglycemia and antioxidant effects because of its large amount of polyphenolic components . This study analyzed hypolipidemic activity properties of an ethanol extract of Rosa damascena by measuring the lipid profile using various doses. Methods: This research is experimental study with randomized post-test only control group design. Twenty male Wistar rats divided into 5 groups; The groups were Healthy Control Group (HCG), Diabetes Group (DG), and Extract Group: P1 (250 mg/kgBW), P2 (500 mg/kgBW), P3 (1000 mg/kgBW). All treatment groups were injected by single-dose streptozotocin 50 mg/kgBW to induce diabetes, and given the Rosa damascena ethanolic extract oral treatment for 2 weeks. Statistical results showed that Rosa damascena significantly decrease cholesterol (58.2±15.19), LDL (11±2.44) optimally in dose 250 mg/KgBW and triglyceride (96.7±44.2) optimally in dose 500 mg/kgBW after 14 days. Conclusion: Rosa damascena extract seems to be great candidate for anti-hyperlipidemic drugs.

Item Type:

Article

Uncontrolled Keywords:

Lipid profile, Rosa damascena, Streptozotocin

Subjects:

R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology

Divisions:

01. Fakultas Kedokteran > Farmakologi

Creators: