Farmindo Hartono, - and Indri Safitri Mukono, - and Maftuchah Rochmanti, - (2020) Effects of Golden Sea Cucumber (Stichopus Hermanii) Ethanol Extracts on Cholesterol Levels of Hypercholesterolemic Rats. Indian Journal of Public Health Research & Development, 11 (5). pp. 650-654. ISSN 0976-0245

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Abstract

Background: Hypercholesterolemia is a condition characterized by an increase in cholesterol level in blood higher than normal limits. Hypercholesterolemia is a risk factor for cardiovascular disease with high mortality. Golden sea cucumbers are known to have antioxidant content. Objectives: This study aims to prove the effect of ethanol extract of golden sea cucumbers (Stichopus hermanii) on cholesterol levels in the blood of hypercholesterolemic rats. Method: This study used a randomized post-test only control group method by randomizing 36 Wistar rats. Rats were divided into 4 groups namely KN, P1, P2, and P3 groups induced with high-fat feed. Ethanol extracts of golden sea cucumbers were given at different doses in the P1 group (4.25 mg/kgBW), P2 (8.5 mg/kgBW), and P3 (17 mg/kgBW) for 14 days. The blood cholesterol level was measured and compared with the KN group given the placebo. Result: In the P1 and P3 groups, LDL levels were higher than in the KN group while in the P2 group were lower. In the measurement of HDL levels, obtained lower HDL levels in all groups of administration compared to the KN group. Total cholesterol and HDL level of all group were lower compared to the KN group. Conclusion: When comparing LDL levels, there were no significant differences between the consenting group and the KN group. When comparing HDL levels, significant differences were seen in the P2 and P3 groups compared to the KN group. In the total cholesterol levels, a significant difference was only seen in the P2 group compared to the KN group.

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