Amanah Fatmadani Suwarno, - (2021) Systematic Review: Pengaruh Arv Pada Laju Transmisi Vertikal Hiv Dari Ibu Yang Menjalani Asi Eksklusif. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Objective: To investigate whether the use of ART in breastfeeding HIV mothers and infants will decrease the rate of transmission of HIV from mother to infant during exclusive breastfeeding period. Design: Systematic review of cross-sectional studies, case control, cohort studies, and prospective studies. Data Sources: Pubmed, LWW Journals, and Science Direct Eligibility criteria for selecting studies: Journals with cross-sectional studies, case control, cohort studies, and prospective studies, must include mothers followed exclusive breastfeeding, and studies were published between 2010-2020. Data extraction: Data from the selected studies will be extracted and compiled. Data included in the extraction are title, author(s), study design, objectives, sample, interventions, measurement, finding(s), and conclusion. Results: A total of 2090 breastfed infants were included among the 2 studies. The first journal included in this systematic review was written by Coovadia et al. and the second was written by Rutagwera et al. Both of these studies were done in Africa. The study conducted by Coovadia et al. was a 3rd phase clinical study to test the efficacy and safety regarding the use of continued nevirapine on HIV exposed infants who received exclusive breastfeeding. This study concluded that the transmission rate for the group that received continued nevirapine was only 1.1%, while those who received placebo reached up to 2.4%. The second journal was conducted by Rutagwera et al. that focuses on the shedding of HIV virus into the breastmilk which is why this study used breastmilk as their sample. Rutagwera et al. found that almost 80% of their subjects shed HIV virus into their breastmilk. This number is correlated to the transmission of HIV vertically in breastfeeding mother. Conclusion: Based on the journals, it can be concluded that the use of ARV does affect the rate of transmission of HIV from mother to child during breastfeeding.

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