Alif Lutvyani, - (2021) Efek Samping Diet Ketogenik Jangka Panjang Terhadap Kadar Kreatinin Serum Sebagai Biomarker Fungsi Ginjal Pada Mus Musculus. Skripsi thesis, UNIVERSITAS AIRLANGGA.
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Abstract
Adverse Event of Long-Term Ketogenic Diet in Serum Creatinine Levels as Biomarker of Kidney Function in Mice Alif Lutvyani1, Artaria Tjempakasari2, Purwo Sri Rejeki3 1 Medicine Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia 2 Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia 3 Department of Physiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia Background: In recent years, ketogenic diet has become a choice not only for overweight or obese people to lose weight, but also for healthy people to maintain health. However, the adverse events of long-term ketogenic diet in kidney are not very clear. The aim of this study was to determine the long-term effect of ketogenic diet on serum creatinine as a biomarker of renal function. Methods: Eighteen male mice (20-30 g) aged 2-3 months were divided into two groups: K1 (standard diet; n=9) and K2 (ketogenic diet; n=9) were given diet for 8 weeks ad libitum. Body weight were measured in pre and post-intervention, serum creatinine levels were measured post-intervention. Serum creatinine levels were measured using a colorimetric assay. Data were analyzed for normality test, independent t-test, and Mann-Whitney using SPSS. Results: Body weight on K1 (17.000±7.089) g, K2 (5.222±4.549) g with p=0.002. Serum creatinine levels on K1 (19.958±4.458) μg/mL, K2 (27.835±7.918) μg/mL with p=0.019. Conclusions: Long-term ketogenic diet increase serum creatinine levels and induced slower body weight gain.
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKA KK FK.PD.207/21 Lut e | |||||||||
| Uncontrolled Keywords: | ketogenic diet, kidney, long-term, mice, serum creatinine | |||||||||
| Subjects: | R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research | |||||||||
| Divisions: | 01. Fakultas Kedokteran > S1 Kedokteran | |||||||||
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| Depositing User: | Mrs Amalia Tri | |||||||||
| Date Deposited: | 28 Oct 2021 04:52 | |||||||||
| Last Modified: | 11 Jan 2022 01:53 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/111742 | |||||||||
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