Shofa, Kambarwati Nur, - (2021) Studi Evaluasi Aktivitas Trombolitik Dari Fermentasi Daun Kelor (Moringa oleifera Lam.) Oleh Saccharomyces cerevisiae FNCC 3210 Dengan Metode Clot Lysis. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background: Thrombolytic agent widely used for the management of cardiovascular diseases. The currently thrombolytic agent like Streptokinase had serious side effects, so there is a need to investigate some more safe natural thrombolytic agents. Natural thrombolytic agents can be found in microorganisms, such as Saccharomyces cerevisiae and plants, such as Moringa oleifera Lam. Both sources of these thrombolytic agents can be combined by fermentation to increase thrombolytic activity. Objective: The aim of this study was to determine the thrombolytic activity of Moringa oleifera extract which was not fermented with thrombolytic activity produced by fermentation of Moringa oleifera by Saccharomyces cerevisiae FNCC 3210. Methods: Fermentation of Moringa oleifera leaf by Saccharomyces cerevisiae FNCC 3210 was carried out for 24 hours. Both samples were dilution with various dilutions in 3:4; 1:2; 1:3 and undiluted, incubated at 37⁰C with various time incubation at 15, 30, 60 and 90 minutes then tested clot lysis. Results: There was no significant increase in thrombolytic activity produced by fermentation of Moringa oleifera by Saccharomyces cerevisiae FNCC 3210 than unfermented Moringa oleifera leaf extract. The greatest thrombolytic activity occurred in Moringa oleifera leaf extract without dilution and the optimum incubation time to produce the greatest thrombolytic activity occurred at 60 minutes. Conclusion: Fermentation of Moringa oleifera leaf by Saccharomyces cerevisiae FNCC 3210 did not increase thrombolytic activity. The thrombolytic activity of Moringa oleifera leaf extract and Moringa oleifera leaf fermented by Saccharomyces cerevisiae FNCC 3210 was affected by dilution and clot lysis incubation time.

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