Amelia, Cordellia Calista, - (2021) Pengaruh Modifikasi EGCG Terhadap Pelepasan EGCG Pada Sediaan Ovula Berbasis κ-Karagenan dan HPMC K100M. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Epigallocatechin gallate (EGCG) is an anti-cervical cancer polyphenol found in green tea that has a low lipophilicity, easily degraded at high temperatures and at pH 6.8. The addition of Tween 80 and Span 80 as non-ionic surfactants has been shown to increase the lipophilicity of EGCG and its become modified. The purpose of this study is to comparing the release of modified EGCG with unmodified EGCG on HPMC K100M and κ-carrageenan-based ovule. Physical characteristics showed that pH of unmodified and modified EGCG ovule were 4.244 ± 0.009 and 4.233 ± 0.0616. Swelling index of unmodified and modified EGCG ovule were 2.946 ± 0.538 and 1.465 ± 0.195. Disintegration time of unmodified and modified EGCG ovules took 60 minutes and 290 minutes to be completely disintegrated. The results of weight diversity both for unmodified and modified EGCG ovules didn’t deviate more than 15% (column A) and more than 30% (column B). Unmodified and modified EGCG ovule had an average hardness of 49.762 kg ± 0.107 and 49.741 kg ± 0.043. Drug Loading results for unmodified and modified EGCG ovule were 0.884 ± 0.065 and 1.146 ± 0.059. The release kinetics of unmodified EGCG ovule followed Higuchi model and modified EGCG ovule followed Korsmeyer-Peppas model with Fickian mechanism. The release rate of unmodified EGCG ovules was 1.4373 ± 0.0731 and the release rate of modified EGCG ovules was 2.4070 ± 0.0291. The result showed that modified EGCG doesn’t decrease the release rate of EGCG on HPMC and κ-carrageenan-based ovule.

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