Two new 2-arylbenzofurans from Sesbania grandiflora L. and their cytotoxicity towards cancer cell

Tjitjik Srie Tjahjandarie, .- and Mulyadi Tanjung, .- and Ratih Dewi Saputri,, .- and Devina Oktari Rahayu, .- and Alfiah Nur Irza Gunawan, .- and Muhammad Fajar Aldin, .- (2020) Two new 2-arylbenzofurans from Sesbania grandiflora L. and their cytotoxicity towards cancer cell. Natural Product Research, 2020. pp. 1-6. ISSN 14786419, 14786427

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Official URL: https://www.tandfonline.com/doi/full/10.1080/14786...

Abstract

Two new 2-arylbenzofurans, sesbagrandiflorain D (1) and E (2) along with two known 2-arylbenzofurans, spinosan A (3) and spinosan B (4) were isolated from the stem bark of Sesbania grandiflora L. The structure of two new compounds established by HRESIMS, 1 D NMR (1H, 13C) and 2 D NMR (HMQC, HMBC) spectra. Compounds (1-4) assayed for their cytotoxicity towards three human cancer cells (MCF-7, HeLa, and WiDr). Compound 1 showed very high activity against MCF-7 and WiDr with an IC50 value of 0.06 and 0.60 μg/mL, respectively.

Item Type: Article
Uncontrolled Keywords: Sesbania grandiflora L, sesbagrandiflorain D and E, 2-arylbenzofuran, cancer cell
Subjects: Q Science
Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: 08. Fakultas Sains dan Teknologi > Kimia
Creators:
CreatorsNIM
Tjitjik Srie Tjahjandarie, .-UNSPECIFIED
Mulyadi Tanjung, .-UNSPECIFIED
Ratih Dewi Saputri,, .-UNSPECIFIED
Devina Oktari Rahayu, .-UNSPECIFIED
Alfiah Nur Irza Gunawan, .-UNSPECIFIED
Muhammad Fajar Aldin, .-UNSPECIFIED
Depositing User: Mr Vega Andi Budiman
Date Deposited: 01 Dec 2021 07:36
Last Modified: 21 Dec 2021 04:04
URI: http://repository.unair.ac.id/id/eprint/112662
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