Cytotoxic Constituents from the Stem Bark of Chisocheton pentandrus

Rurini Retnowati*, .- and Hermin Sulistyarti, .- and Nikmatus Zahro Wahidah, .- and Anisa Lailatusy Syarifah, .- and Suprianto Salam, .- and Nurlelasari, .- and Agus Safari, .- and Desi Harneti, .- and Mulyadi Tanjung, .- and Ace Tatang Hidayat, .- and Rani Maharani, .- and Unang Supratman, .- and Yoshihito Shiono, .- (2021) Cytotoxic Constituents from the Stem Bark of Chisocheton pentandrus. Natural Product Sciences, 27 (1). pp. 18-27. ISSN 12263907

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Official URL: http://www.koreascience.kr/article/JAKO20211246186...

Abstract

Abstract  Eight cytotoxic constituents, consisting of six triterpenoids, cabralealactone (1), cabraleadiol (2), prototiamin A (3), 23-desmethyllimocin B (5), melianodiol (7) and indicalilacol (8) along with one limonoid, neemfruitins A (4) and one protolimonoid, protoxylocarpin G (6), were isolated from the extract of n-hexane of the stembark of Chisocheton pentandrus. The chemical structures were identified on the basis of spectroscopic evidence and compared to previously reported spectra. These isolated compounds appear for the first time in the plant. Compounds 1 - 8 were evaluated for their cytotoxic effect against MCF-7 breast cancer lines in vitro. Among the isolated compounds, melianodiol (7) showed the strongest cytotoxic activity with IC50 values of 16.8 M.

Item Type: Article
Uncontrolled Keywords: Chisocheton pentandrus, MCF-7 cell lines, Meliaceae, limonoid, triterpenoids
Subjects: Q Science
Q Science > QD Chemistry
Divisions: 08. Fakultas Sains dan Teknologi > Kimia
Creators:
CreatorsNIM
Rurini Retnowati*, .-UNSPECIFIED
Hermin Sulistyarti, .-UNSPECIFIED
Nikmatus Zahro Wahidah, .-UNSPECIFIED
Anisa Lailatusy Syarifah, .-UNSPECIFIED
Suprianto Salam, .-UNSPECIFIED
Nurlelasari, .-UNSPECIFIED
Agus Safari, .-UNSPECIFIED
Desi Harneti, .-UNSPECIFIED
Mulyadi Tanjung, .-UNSPECIFIED
Ace Tatang Hidayat, .-UNSPECIFIED
Rani Maharani, .-UNSPECIFIED
Unang Supratman, .-UNSPECIFIED
Yoshihito Shiono, .-UNSPECIFIED
Depositing User: Mr Vega Andi Budiman
Date Deposited: 01 Dec 2021 07:38
Last Modified: 21 Dec 2021 04:05
URI: http://repository.unair.ac.id/id/eprint/112666
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