Winwati Eka Putri, - and Anang Endaryanto, - and Fedik Abdul Rantam, - and Cita Rosita Sigit Prakoeswa, - (2019) Mesenchymal Stem Cells-Conditioned Medium (SECRETOME) in Skin Aging: A Systematic Review. INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH, 13 (2). pp. 613-635. ISSN 0975-2366

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Abstract

Background: The skin aging is the most important factor that constitutes the general "well-being" and perception of "health" in humans. The mesenchymal stem cells (MSCs) have a therapeutic effect on anti-apoptosis, angiogenic, immunomodulatory and chemo-existing activity, especially in its treatment. However, the use of mesenchymal stem cell-conditioned medium (MSC-CM) as skin aging therapy requires further investigation. Methods: The systematic literature search have the following keywords; conditioned media or conditioned medium or secretome as well as photoaging or skin aging. A total of 283 articles were reviewed from Pubmed, Wiley Online Library, Science Direct and The Cochrane Library, and only 11 articles were relevant for this systematic review. Results: The results show that Secretome is promising in improving the skin aging process. However, due to the high heterogeneity, a meta-analysis cannot be performed. Conclusion: The use of secretome was promising in improving skin aging process, as shown by the available preclinical studies. However, further clinical studies are needed to confirm the benefits and effects of secretome.

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