Bambang Purwanto, - and Sundari Indah Wiyasihati, - and Putri Ayu Masyitha, - and Kristanti Wanito Wigati, - and Irfiansyah Irwadi, - (2019) Golden sea cucumber extract revives glucose transporter-4 and interleukin-6 protein level in diabetic mouse muscle. Veterinary World, 12 (5). pp. 684-688. ISSN 2231-0916

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Abstract

Background: Streptozotocin (STZ)-induced free radical oxidant activity resulted in muscle wasting due to protein carbonyl (PC), glucose transporter-4 (Glut-4), and interleukin-6 (IL-6) protein alteration. Antioxidant ingredient in the golden sea cucumber extract was found in promising level to inhibit free radical activity. Aim: This study was aimed to investigate the effect of golden sea cucumber extract on PC, IL-6, and Glut-4 level of STZ-induced diabetes mouse. Materials and Methods: This study was performed using mice, which were grouped into non-diabetes, diabetes, and diabetes-treated extract groups. The golden sea cucumber was extracted using 70% ethanol, which was administered by oral gavage twice a day for 5 consecutive days. Results: The extract reduced PC level and improved muscle Glut-4 and IL-6 protein level of diabetic mouse. Conclusion: The extract of golden sea cucumber revived muscle Glut-4 and IL-6 protein level in protection against muscle wasting.

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