Tin Myo Thant, .- and Nanik Siti Aminah, .- and Alfinda Novi Kristanti, .- and Rico Ramadhan, .- and Preecha Phuwapraisirisan, .- and Yoshiaki Takaya, .- (2021) A new pyrano coumarin from Clausena excavata roots displaying dual inhibition against α-glucosidase and free radical. Natural Product Research, 35 (1). pp. 556-561. ISSN 1478- 6419 (online)

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Abstract

A new pyrano coumarin, identified as excavatin A (1) together with two known compounds nordentatin (2) and binorpocitrin (3) was isolated from the 95% EtOH extract of Clausena excavata. All structures were elucidated by using spectroscopy methods such as extensive NMR and HR-FAB-MS spectrometry. All the isolated compounds were tested on antidiabetes activity by using α-glucosidase inhibition assay and the antioxidant activity by DPPH assay. Compounds 1-3 showed antioxidant activity with IC50 values 0.286, 0.02, 0.278 mM. Among them, 2 exhibited inhibition activity against maltase (IC50 5.45 µM) and sucrase (IC50 43.57 µM). However, compounds (1) and (3) displayed inhibition on yeast α-glucosidase with IC50 values 1.92 and 5.58 mM.

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