Izzuki Muhashonah, - and Juli Soemarsono, - and Puspa Wardhani, - and Aryati, - (2014) Immature Platelet Fraction di Demam Dengue dan Demam Berdarah Dengue (Immature Platelet Fraction in Dengue Fever and Dengue Hemorrhagic Fever). Indonesian Journal of Clinical Pathology and Medical Laboratory, 21 (1). pp. 40-44. ISSN 0854-4263

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Abstract

Thrombocytopenia is a hematological abnormality found in the majority of Dengue Virus Infection cases with manifestations such as Dengue Fever (DF) and Dengue Hemorrhagic Fever (DHF). Bone marrow response to the decrease in platelets is by increasing thrombopoiesis which can be identified by Immature Platelet Fraction (IPF) examination as an indirect indicator of bone marrow response to thrombocytopenia. The examination of IPF in venous blood was performed on 29 subjects who met the 1997 WHO criteria, carried out from January until August 2012. The EDTA blood samples were examined twice, on the day of their admittance and two days later, based on a flowcytometry principle using Sysmex XE-2100. The IPF was derived from the immature platelet ratio against the total number of platelets (IPF %). The test results were statistically analyzed by using SPSS 20. It was found, that IPF in DHF compared between the first and the third day of their admittance was statistically significantly different with p = 0.033 compared to DF with p = 0.444. The Pearson’s correlation showed an inverse correlation between IPF and platelets with r = -0.675 and p = 0.01. The statistical analysis revealed a significant difference in IPF between moderate- and mild-thrombocytopenia on the first and third day of their admittance with p = 0.014 and 0.001, respectively. Based on this study it can be concluded that IPF can be used to indicate the bone marrow response in both DF and DHF related to thrombocytopenia.

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