K N W Tun, .- and N S Aminah, .- and A N Kristanti and R Ramadhan, .- and Y Takaya, .- (2019) Two flavonoids from stem bark of Casimiroa edulis and theisr antidabetic and antioxidant activities. In: IOP Conference Series : Earth and Environmental Science. IOP Publishing, Atlanta, GA. US, pp. 1-5.

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Abstract

Casimiroa edulis Llave et Lex (Rutacae), popularly known as white sapote. The main aim of this study is to isolate and investigate the bioassay of the stem bark of Casimiroa edulis. Two flavonoids were isolated from the methanolic fraction of the stem bark of Casimiroa edulis. The isolated compounds can be identified as 6,7-dimethoxyflavone (1) and 5,6,2-trimethoxyflavone (2) by using advance spectroscopic methods, including FT-IR, UV, 1D NMR, 2D NMR. Compounds 1 and 2 were evaluated for their antidiabetic and antioxidant activities. The result revealed that the two compounds did not have antidiabetic activity and antioxidant activity. This is the first phytochemical study of 6,7-dimethoxyflavone from the genus Casimiroa.

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